A gene identified as PSEN1 is related to a rare form of Alzheimer's disease, which has been studied for 25 years. More than 100 people affected by this disease have been found, mainly in Mexico, especially in Jalisco, as well as in other regions such as Mexico City, Michoacán, and Guanajuato. It is suggested that this phenomenon may be attributed to a common ancestor who developed this form of Alzheimer's many years ago.
The PSEN1 gene was initially located in 1993 as one of the three genes responsible for causing Alzheimer's disease. Over the years, more than 200 different variations of this gene have been identified worldwide, each causing the disease. Symptoms include memory and language problems, behavioral changes, anxiety, motor difficulties, and leg stiffness.
Dr. Luis Figuera in Guadalajara and Dr. John Ringman in Los Angeles have worked together to detect between 100 and 150 families with the PSEN1 gene mutation in Mexico. It is estimated that by 2050, more than 3.5 million Mexicans will suffer from Alzheimer's-type dementia. This genetic mutation in Jalisco typically manifests in patients from the age of 40, indicating a hereditary predisposition in Jalisco families.
Dr. Ringman emphasizes that 25 years ago they started the study in Los Angeles, finding genetic similarities in patients from Jalisco and currently have identified the mutation in more than 150 people from various families. Advances in research have allowed for a better understanding of this devastating disease and its impact on the Mexican population, according to data from the Ministry of Health and its strategies to address it.
